Selank Overview

Selank is a synthetic heptapeptide analog of tuftsin, a natural immunomodulatory fragment of IgG. It is studied in preclinical and laboratory models for its influence on neurotransmitter regulation, stress response pathways, and immune signaling. Research has examined Selank’s role in modulating GABAergic activity, monoamine metabolism, and cytokine balance.

Ashmarin I.P. et al. (1998).

History

Selank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1990s as a synthetic analog of tuftsin, modified for improved stability and activity. Early studies explored its immunomodulatory and anxiolytic properties, leading to broader investigations of its effects on neuropeptide signaling, cognitive processes, and systemic immune regulation in preclinical models.

Zozulya A.A. et al. (2008).

Selank Structure

CAS #: 129954-34-3

Molecular Formula: C₃₄H₅₇N₁₁O₉

Molecular Weight: 751.9 g/mol

PubChem ID: 56841944

Research Findings

Selank has been studied in neurological, immune, and systemic models, with research highlighting its role in neuropeptide signaling, stress response, and immune regulation. Studies also report activity in neurotransmitter modulation, cytokine balance, and protective responses in preclinical settings.

Key Areas of Research:

• Neurological: neurotransmitters, stress response, signaling

• Immune: cytokine balance, regulation, modulation

• Systemic: protection, recovery, resilience

Together, these findings suggest broad experimental potential for Selank across neurological, immune, and systemic pathways. By modulating neurotransmitter activity and supporting immune balance, Selank provides a versatile platform for research into stress biology, immune regulation, and systemic resilience in laboratory models.

Inozemtsev A.N. et al., 2008

References

Ashmarin I.P. et al. (1998). Immunomodulatory and neurochemical properties of Selank in preclinical models. Neurosci Behav Physiol, 28(3):241–246. 

Zozulya A.A. et al. (2008). Neuroimmune mechanisms of Selank: cytokine modulation in research models. Bull Exp Biol Med, 145(5):577–580.

Inozemtsev A.N. et al. (2008). Selank and the regulation of gene expression linked to synaptic plasticity in animal models. Bull Exp Biol Med, 146(4):439–442.